NABOTA 100U

Nabota 100U is the standard format of Daewoong Pharmaceutical's botulinum toxin type A preparation: 100 units as a lyophilisate, which is reconstituted with sterile saline solution before use. If you are comparing Nabota to your current toxin for the first time, this is the size to start with – it corresponds to the format that dosage literature and price comparisons in the market typically refer to.

100 units: the reference format in the toxin market

The 100-unit bottle is not the most common presentation by chance. It has become established as a reference point around which almost everything is measured: dosage information in specialist literature, comparison tables between preparations, wholesale prices. Even Nuceiva – the trade name under which the same active ingredient is approved in the EU – is presented as a 100-unit bottle.

In practice, this means two things. First, empirical data from studies and specialist articles can be transferred without conversion. Second, it determines the ideal starting quantity for a product trial: enough material for several treatments, without having a large bottle sitting in the refrigerator if the results are unsatisfactory.

Why botulinum toxins cannot be compared based on price per unit

This is the most common mistake when buying toxins, and it costs more money than it saves.

The calculation "bottle price divided by units" seems obvious, but it assumes that a unit means the same thing for all manufacturers. This is not the case. The unit definition is based on manufacturers' own testing procedures, which differ in methodology and reference. Two products with the same number of units on the label may require different doses in use.

The reliable benchmark is therefore not the price per unit, but the price per treatment at the dose you actually need . And you only know that after you have used the product.

Three factors that are usually missing from this calculation:

• Your actual dose after switching – not the usual number of units from the previous medication.
• The waste : Partially used bottles are discarded. With inconsistent capacity, a significant portion of what appears to be a bargain ends up in the trash.
• The chosen dilution determines how many injection points you can effectively use from one bottle.

In practical terms, this means that a product test with a 100-unit bottle and clearly documented doses provides a more reliable basis for decision-making than any price list.

Reconstitution and dilution scheme for 100 units

Nabota is a lyophilisate and is dissolved in sterile, preservative-free 0.9% sodium chloride solution before use. The volume added determines how many units are contained in 0.1 ml.

The values are purely theoretical, not recommendations. The appropriate dilution in each individual case depends on the area being treated and the injection technique – the official manufacturer's instructions and the applicable technical information are decisive.

A dilution, bindingly specified.

When multiple people are preparing medication in a practice, the dilution volume should be specified in writing and documented in the treatment protocol. The reason is simple: with a 2.5 ml addition, 0.1 ml represents four units, while with 4 ml it only represents two and a half. The same marking on the syringe then represents two different doses – and no one can tell from the drawn-up solution which one is currently being used.

After dissolving

The saline solution is added along the side of the bottle, then gently swirled, not shaken: Botulinum toxin is a protein and sensitive to shear forces. The reconstituted solution should be kept refrigerated and used within the time frame specified by the manufacturer. Any remaining solution should be disposed of properly.

Nabota 100U – Product Data

Nabota, Jeuveau and Nuceiva briefly categorized

The same active ingredient from Daewoong carries a different trade name depending on the market: Nabota in Korea, Jeuveau in the USA, and Nuceiva in the European Union. The marketing authorization holder and presentation also differ – the Korean Nabota product is not the EU-approved Nuceiva.

We have described the complete classification, including registration data and marketers, in more detail on the Nabota 200U page .

Areas of application and dosage

The specific applications covered depend on the respective approval in the country of use. Botulinum toxin type A is used in the medical field for selected therapeutic and aesthetic treatments.

The dose is determined individually based on the indication, muscle activity, severity of the condition, and the treating physician's clinical experience. Dosage recommendations vary significantly depending on the treatment area and should only be derived from the official prescribing information. The treating physician is responsible for deciding on the indication, dosage, and injection technique.

Onset of action and duration of treatment

The effects can begin within a few days of treatment. The maximum clinical result is often observed after about two weeks – the usual time for follow-up and, if necessary, adjustment. The duration of the effect varies from person to person and is influenced by factors such as the treatment area, the dose administered, and patient-specific factors.

Preparation and handling

Before use, the official manufacturer's instructions must be followed. Reconstitution, drawing up, and administration must be performed under strict aseptic conditions. After reconstitution, the solution should be visually inspected: clear, colorless, and free from visible particles. Cloudiness, discoloration, or particles preclude use.

Batch number and expiry date are recorded before use. Any unused portion must be disposed of in accordance with applicable regulations.

Storage, cold chain and shipping

Storage, transport, and use should be carried out according to the official manufacturer's instructions, generally at 2–8 °C and protected from light. Do not freeze. After reconstitution, strict adherence to the cold chain is required; in this respect, the preparation behaves like any ready-to-use protein solution.

Safety, contraindications and side effects

A complete medical history must be taken before each treatment. The preparation should not be used in cases of known contraindications or hypersensitivity to any of its components, or if, in the opinion of a physician, there are medical reasons against treatment – these include, in particular, neuromuscular diseases, infections at the injection site, as well as pregnancy and breastfeeding.

Pain, redness, swelling, or bruising at the injection site, as well as headaches, are frequently reported side effects. Depending on the treatment area, temporary functional changes may occur, such as ptosis or asymmetrical facial expression. Patients should be fully informed about the benefits, potential risks, and expected outcome—including rare signs of toxin spread, such as difficulty swallowing, speaking, or seeing, pronounced muscle weakness, or breathing difficulties, which require immediate medical attention.

Nabota 100U or 200U – which bottle size fits?

Both bottles contain the same preparation. The difference is the quantity – and therefore the question of how predictable your capacity utilization is.

Conversely, if you wish to completely forgo the reconstitution step, we offer Innotox 100U as a ready-to-use alternative – a ready-to-use solution with a fixed concentration of 4 units of 0.1 ml each, also available as Innotox 50U for smaller requirements . Different manufacturer, different unit system: The dose cannot be transferred.

Frequently asked questions about Nabota 100U

How many units are there after dissolving in 0.1 ml?

This depends on the dilution volume: 4 units for 2.5 ml, 5 units for 2 ml, and 10 units for 1 ml. The complete overview is shown in the dilution chart above.

What is Nabota 100U reconstituted with?

Add sterile, preservative-free 0.9% sodium chloride solution. Pour the solution along the side of the bottle and swirl gently, do not shake.

Is the 200ml bottle worth it compared to two 100ml bottles?

Only with predictable capacity utilization. Since leftover quantities are discarded, the actual usage per bottle is the deciding factor – two smaller containers can be more economical than one with twice the contents if appointments are irregular. Details can be found on the Nabota 200U page .

Can I compare Nabota units with my current medication?

No. The units of measurement from different botulinum toxin manufacturers are based on their own testing procedures and are not directly convertible. Switching manufacturers requires determining the correct dosage – for the same reason, comparing prices per unit is misleading.

Is Nabota "Korean Botox"?

The term is used colloquially, but it is technically incorrect. Botox® is a registered trademark of Allergan for a different product. Nabota is a product of Daewoong. Both contain botulinum toxin type A, but they are different medications.

Does Nabota need to be refrigerated?

Yes, according to the manufacturer's instructions, generally at 2–8 °C and protected from light. Do not freeze. After reconstitution, the manufacturer's specifications regarding the shelf life apply.

Does Nabota exist without reconstitution?

Nabota itself is a lyophilisate. If you are looking for a ready-to-use toxin, Innotox 100U is the appropriate alternative – a different preparation from a different manufacturer, with a fixed concentration.